"Kynurenine Pathway and Diseases Associated With Its Dysfunction "

Abstract: The kynurenine pathway is a metabolic mechanism that results in the synthesis of nicotinamide adenine dinucleotide. Tryptophan, kynurenine, kynurenic acid, xanthurenic acid, quinolinic acid, and 3-hydroxykynurenine are among the metabolites involved to the kynurenine pathway. About 95% of the entire catabolism of tryptophan is attributed to the kynurenine pathway. Certain genetic and psychiatric disorders are linked to pathway disruption. The present review article deals with the diseases and disorders that have been attributed to dysfunction/dysregulation of kynurenine pathway